I like to think I am pretty sensitive to subjects like Racism, but I'm not sure that had I played the original version of the game that created all of the who har in the first place that I would have associated Racism with it. At least not the two sections from the demo before they were changed.
Whether this is because, as a gamer, you spend an awful lot of time shooting at 3D models that represent Nazi's, Japanese etc, you become desensitized to it I don't know.
Different cultures are, to a lesser or greater degree, sensitive to things like this. The argument that Resi 4 portrayed Spanish in the way it did doesn't really hold up though as generally your average Spanish peasant wasn't persecuted in the same way (unless it was by their own leaders).